Evolution from one autoimmune disorder to another. Epitope spreading?
نویسندگان
چکیده
منابع مشابه
Epitope spreading: a mechanism for progression of autoimmune disease.
Autoimmune diseases are typically characterized by a persistent inflammatory self-recognition process that ultimately leads to chronic progressive disability. Over the past several years we have addressed the fundamental question of why autoimmune diseases are chronic. Our working hypothesis in these studies has been that autoimmunity involves a continuous acquisition of new self-recognition ev...
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INTRODUCTION Anti-citrullinated protein antibodies have a diagnostic role in rheumatoid arthritis (RA); however, little is known about their origins and contribution to pathogenesis. Citrullination is the post-translational conversion of arginine to citrulline by peptidyl arginine deiminase, and increased citrullination of proteins is observed in the joint tissue in RA and in brain tissue in mu...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2018
ISSN: 0300-9475
DOI: 10.1111/sji.12657